PIAS1 (C) Antibody, Mouse Monoclonal

SKU: orb66686

Description

Mouse monoclonal to PIAS1.PIAS1 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator oftranscription)] family of transcriptional modulators. PIAS1 functions as an E3 small ubiquitin-likemodifier (SUMO) ligase. It stabilizes the interaction between UBE2I and the substrate, and functionsas a SUMO-tethering factor. PIAS1 plays an important role in the transcriptional regulation ofnumerous cellular pathways, including STAT, NF-B, p53 and the steroid hormone signalingpathways. Recent studies revealed that PIAS1 is an important regulator for innate immunity,inflammatory cytokine signaling and regulatory T cell differentiation.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:1000-1:5000
Reactivity	Mouse

Key Properties

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Host	Mouse
Clonality	Monoclonal
Immunogen	C-terminal region of mouse PIAS1
Molecular Weight	72
Purity	Caprylic Acid-Ammonium Sulfate precipitation
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.02% Thimerosal
Disclaimer	For research use only

Alternative Names

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anti-PIAS1 antibody,anti-Protein inhibitor of activated STAT1 antibody,anti-Pias1 antibody,anti-DEAD antibody,anti-H boxbinding protein 1 antibody,anti-Ddxbp1 antibody

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Western blot analysis of total cell extracts from mouse thymus using PIAS1 antibody

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UniProt

O88907

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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