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Pilocarpine Hydrochloride

SKU: orb1310276

Description

Pilocarpine Hydrochloride is a selective M3 muscarinic acetylcholine receptor agonist. It is widely utilized in neuroscience research, particularly for establishing in vivo models of temporal lobe epilepsy and for studying cholinergic signaling in various in vitro assays.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number54-71-7
MW244.72
Purity99.89%
FormulaC11H16N2O2·HCl
SMILESCl.CCC1C(Cc2cncn2C)COC1=O
TargetAChR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.35 mM);DMSO:138 mg/mL (563.91 mM);H2O:24.5 mg/mL (100.11 mM)

Bioactivity

Target IC50
Astrocytes:31.86 mM|Coumarin 7-hydroxylase (mouse liver microsomes):6 μM|dimethylnitrosamine N-demethylase (mouse liver microsomes):100 μM|Testosterone 15 alpha-hydroxylase (mouse liver microsomes):6 μM|coumarin 7-hydroxylase (human liver microsomes):6 μM|Pentoxyresorufin O-dealkylas (mouse liver microsomes):4 μM|dimethylnitrosamine N-demethylase (human liver microsomes):10 μM|CYP2A6 (human liver microsomes):5.31μM|testosterone 6 beta-hydroxylase (mouse liver microsomes):> 1 mM
In Vivo
METHODS: To study the effect of Pilocarpine Hydrochloride on salivary secretion, Pilocarpine Hydrochloride (0.5 mg/kg) was injected into rats. RESULTS: The salivary secretion volume of exercise group was significantly higher than that of control group (P<0.01). On the contrary, the Na+ concentration in saliva of the exercise group was significantly lower than that of the control group (P<0.05).

Storage & Handling

StoragePowder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(+)-Pilocarpine hydrochloride, Inhibitor, inhibit, Muscarinic acetylcholine receptor, NSC 5746 HCl, mAChR, Pilocarpine, Pilocarpine HCl, Pilocarpine Hydrochloride,

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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20 mg
$ 110.00
DispatchUsually dispatched within 3-5 working days
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