Pilocarpine Hydrochloride

SKU: orb1310276

Description

Pilocarpine Hydrochloride is a selective M3 muscarinic acetylcholine receptor agonist. It is widely utilized in neuroscience research, particularly for establishing in vivo models of temporal lobe epilepsy and for studying cholinergic signaling in various in vitro assays.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	54-71-7
MW	244.72
Purity	99.89%
Formula	C₁₁H₁₆N₂O₂·HCl
SMILES	Cl.CCC1C(Cc2cncn2C)COC1=O
Target	AChR
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.35 mM);DMSO:138 mg/mL (563.91 mM);H2O:24.5 mg/mL (100.11 mM)

Bioactivity

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Target IC50

Astrocytes:31.86 mM|Coumarin 7-hydroxylase (mouse liver microsomes):6 μM|dimethylnitrosamine N-demethylase (mouse liver microsomes):100 μM|Testosterone 15 alpha-hydroxylase (mouse liver microsomes):6 μM|coumarin 7-hydroxylase (human liver microsomes):6 μM|Pentoxyresorufin O-dealkylas (mouse liver microsomes):4 μM|dimethylnitrosamine N-demethylase (human liver microsomes):10 μM|CYP2A6 (human liver microsomes):5.31μM|testosterone 6 beta-hydroxylase (mouse liver microsomes):> 1 mM

Storage & Handling

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Storage	Powder: -20°C for 3 years \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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(+)-Pilocarpine hydrochloride, Inhibitor, inhibit, Muscarinic acetylcholine receptor, NSC 5746 HCl, mAChR, Pilocarpine, Pilocarpine HCl, Pilocarpine Hydrochloride,

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Compound Identifiers

PubChem CID

120104 ↗

Key Properties

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No computed properties available.

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