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PIM1-IN-8

SKU: orb3136034

Description

PIM1-IN-8 is an inhibitor targeting the PIM1/p65 signaling pathway. It suppresses the expression of α-SMA and type I collagen in activated fibroblasts and inhibits TGF-β-induced migration. In a Bleomycin (BLM)-induced pulmonary fibrosis mouse model, PIM1-IN-8 alleviates lung fibrosis. This compound can be utilized in research on idiopathic pulmonary fibrosis (IPF).

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

TargetInterleukin,Pim,NF-κB

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information