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PLM-101

SKU: orb2278343

Description

PLM-101 is an orally active small molecule anticancer agent targeting FLT3 and RET for acute myeloid leukemia research. It induces FLT3 degradation via autophagy and inhibits PI3K and Ras/ERK signaling. Its efficacy has been validated in vitro and in vivo, including in mouse MV4-11 xenograft models at oral doses of 3-40 mg/kg.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Images & Validation

Key Properties

MW407.44
FormulaC22H22FN5O2
Targetc-RET,FLT,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

PLM-101 (orb2278343)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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