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PNU112455A hydrochloride

SKU: orb1299104

Description

PNU112455A hydrochloride is a competitive ATP-binding site inhibitor of CDK2 and CDK5, exhibiting K<sub>m</sub> values of 3.6 µM and 3.2 µM, respectively. This small molecule is a research tool for studying cell cycle regulation and neuronal function in vitro, with applications in oncology and neurodegenerative disease research.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number21886-12-4
MW301.75
Purity98.58% (May vary between batches)
FormulaC10H12ClN5O2S
SMILESCl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1
TargetCDK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.26 mM);DMSO:125 mg/mL (414.25 mM)

Bioactivity

Target IC50
CDK5:3.2 μM (Km)|CDK2:3.6 μM (Km)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

site, PNU112455A, PNU-112455A hydrochloride, PNU 112455A, PNU 112455A HCL, anticooperative, ATP, Alzheimer's, CDK
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 150.00
25 mg
$ 240.00
50 mg
$ 340.00
100 mg
$ 530.00
500 mg
$ 1,110.00
DispatchUsually dispatched within 5-10 working days
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