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PPL agonist-1

SKU: orb2814432

Description

PPL agonist-1 (Compound I-3) is a selective periplakin (PPL) agonist that elevates cAMP, upregulates MITF, and modulates tryptophan metabolism to stimulate melanogenesis. It demonstrates superior efficacy to Ruxolitinib in preclinical models, showing potential for vitiligo research in both cellular and animal studies.

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number3040997-52-9
MW507.54
FormulaC25H22FN5O4S
SMILESCC=1C=C(C2=CC=C([C@@H](NC=3N=C(NS(=O)(=O)C4=CC(N(=O)=O)=CC=C4)C=CN3)C)C=C2)C=CC1F
TargetMicrotubule Associated,Tyrosinase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information