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Pramipexole

SKU: orb1227067

Description

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Parkinson's Disease Approved.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Pramipexole

Key Properties

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CAS Number104632-26-0
MW211.3271
Purity>98% (HPLC)
FormulaC10H17N3S
SMILESCCCN[C@H](C1)CCC2=C1SC(N)=N2
TargetDopamine Receptor
Solubility10 mM in DMSO

Bioactivity

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In Vivo
Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals. Pramipexole improves neurological recovery. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Animal model: Male Wistar rats weighing 250-300 g (16-18 weeks old). Dosage: 0.25 mg/kg, 1 mg/kg. Administration: Intraperitoneal injection. Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
In Vitro
Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50, 000 nM. Pramipexole (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size. Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Pramipexole | Oprymea | Pramipexol | Pramipexolum

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Quick Database Links

Gene Symbol
Dopamine Receptor

Protocol Information

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500 mg
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