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PRO-905

SKU: orb3132776

Description

Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395.

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Key Properties

CAS Number2762209-68-5
MW568.54
FormulaC22H29N6O8PS
SMILESS=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OC(C)C)=O)C)=O)[C@@H](O)[C@H]3O)NC(N)=N1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

PRO-905 (orb3132776)

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