Propyl pyrazole triol

SKU: orb1307858

Description

Propyl pyrazole triol (PPT) is a potent and selective ERα agonist, exhibiting approximately 410-fold greater binding affinity for ERα over ERβ. It is widely used as a research tool in vitro and in vivo to investigate ERα-specific signaling pathways in endocrinology, oncology, and developmental biology.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	263717-53-9
MW	386.44
Purity	98.39%
Formula	C₂₄H₂₂N₂O₃
SMILES	CCCc1c(nn(c1-c1ccc(O)cc1)-c1ccc(O)cc1)-c1ccc(O)cc1
Target	Estrogen/progestogen Receptor,Estrogen Receptor/ERR
Solubility	DMSO:99 mg/mL (256.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (25.88 mM)

Bioactivity

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Target IC50	ERα:140 pM(EC50)
In Vitro	In ERα-U2OS-Luc cells, the EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Estrogen receptor alpha, Estrogen Receptor, Estrogen Receptor/ERR, EstrogenReceptor, ERR, ERα, Inhibitor, inhibit, Propyl pyrazole triol, progestogenReceptor, progestogen Receptor, PPT

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Compound Identifiers

PubChem CID

5040063 ↗

Key Properties

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No computed properties available.

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