PROTAC AR/AR-V7 degrader-1

SKU: orb2565428

Description

PROTAC AR/AR-V7 degrader-1 (27c) is a bifunctional small molecule that simultaneously degrades full-length AR and the AR-V7 splice variant, with DC50 values of approximately 2.7 µM. It induces apoptosis and is a valuable chemical tool for studying androgen receptor signaling and resistance mechanisms in prostate cancer research, both in vitro and in vivo.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2841308-96-9
MW	485.43
Formula	C₂₄H₁₉F₄N₅O₂
SMILES	O=C1N(C(=O)C(C)(C)N1CCNC=2C3=C(C(F)=CC2)N=CC=C3)C4=CC(C(F)(F)F)=C(C#N)C=C4
Target	PROTACs,Apoptosis,Adrenergic Receptor

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

162351884 ↗

Key Properties

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No computed properties available.

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