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PROTAC HDAC8 Degrader-2

SKU: orb2695440

Description

PROTAC HDAC8 Degrader-2 (compound 32a) is a heterobifunctional degrader that recruits the CRBN E3 ligase to degrade HDAC8 (DC50 = 8.9 nM) and HDAC6 (DC50 = 14.3 nM). It is a valuable chemical tool for probing HDAC isoform functions in cancer and neurobiology research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW780.83
FormulaC39H44N10O8
SMILESO=C(NC=1C=CC(=CC1)C2=NN(C(=O)CC2C)CCCCCN)N3CC=4C=NC=CC4C3
TargetPROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information