PROTAC JAK1/2 degrader-1

SKU: orb3176665

Description

PROTACJAK1/2 degrader-1 (Compound A8) is a selective JAK1/2 PROTAC degrader with DC50 values of 1.4 μM for JAK1 and 0.92 μM for JAK2. It effectively inhibits the release of NO, IL-6 (IC50= 12.89 μM), and TNF-α (IC50= 17.17 μM). This compound alleviates inflammatory responses and colon damage by hindering the JAK/STAT3 signaling pathway, making it useful for studying colitis.

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Key Properties

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Target	Interleukin,STAT,PROTACs,TNF,JAK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Interleukin,STAT,PROTACs,TNF,JAK

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