PROTAC JAK1/2 degrader-1

PROTACJAK1/2 degrader-1 (Compound A8) is a selective JAK1/2 PROTAC degrader with DC50 values of 1.4 μM for JAK1 and 0.92 μM for JAK2. It effectively inhibits the release of NO, IL-6 (IC50= 12.89 μM), and TNF-α (IC50= 17.17 μM). This compound alleviates inflammatory responses and colon damage by hindering the JAK/STAT3 signaling pathway, making it useful for studying colitis.