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Proteasome inhibitor IX

SKU: orb1306175

Description

Proteasome inhibitor IX

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number856849-35-9
MW377.01
Purity99.77% (May vary between batches)
FormulaC20H21B2NO5
SMILESCN1C\C(=C\c2ccc(cc2)B(O)O)C(=O)\C(C1)=C/c1ccc(cc1)B(O)O
TargetProteasome
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.65 mM);DMSO:40 mg/mL (106.1 mM)

Bioactivity

Target IC50
20S proteasome:1 μM
In Vitro
AM114 exhibits potent activity against p53+/+ cells in colony formation assay, with an IC50 value of 0.6 μM. AM114 treatment inhibits the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells. In HCT116 p53+/+ cells, AM114(0.1-10 μM) treatment causes a loss of cell survival in the p53+/+ and p53-/- cells by approximately 70 and 20%, respectively at a concentration of 1 μM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cytotoxic, Chalcone, chymotrypsin-like, Anticancer, boronic, AM 114, AM114, AM-114, acid, 20S, 20S proteasome, Inhibitor, EGCG, p53, inhibit, ubiquitinated, Proteasome inhibitor IX, Proteasome, PS-IX
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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10 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 80.00
25 mg
$ 110.00
50 mg
$ 160.00
100 mg
$ 230.00
500 mg
$ 500.00
DispatchUsually dispatched within 5-10 working days
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