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Proxyfan

SKU: orb1704201

Description

Proxyfan is a protean histamine H3 receptor ligand exhibiting a spectrum of activities from full agonist to inverse agonist, dependent on receptor conformation. It serves as a neutral antagonist in hypothalamic feeding circuits and an agonist in the basolateral amygdala, making it a valuable tool for studying H3 receptor function in neuropharmacology and behavior.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number177708-09-7
MW216.28
Purity99.68% (May vary between batches)
FormulaC13H16N2O
SMILESN1=CNC(=C1)CCCOCC=2C=CC=CC2
TargetHistamine Receptor
SolubilityDMSO:4 mg/mL (18.49 mM);H2O:4 mg/mL (18.49 mM)

Bioactivity

Target IC50
H3LR (rat):2.9 nM (Ki)|H3LR (human):2.7 nM (Ki)
In Vivo
The H3 receptor neutral antagonist Proxyfan was used in rats using intraperitoneal injection. Proxyfan (0.2–5.0 mg/kg) did not affect food intake in freely feeding rats during either the light or dark phase. At night, proxyfan antagonized the orexigenic effect of the H3 agonist imetit (10 mg/kg) and the anorectic effect of the inverse agonist thioperamide (2 mg/kg).
In Vitro
Proxyfan is the neutral antagonist of histamine H3 receptors, with Ki values of 2.9 nM for rat and 2.7 nM for human H3 receptors.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Proxifan, Proxyfan oxalate, Proxyfan Oxalate

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 340.00
5 mg
$ 770.00
10 mg
$ 1,030.00
25 mg
$ 1,560.00
50 mg
$ 2,020.00
100 mg
$ 2,540.00
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