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PS372424 hydrochloride

SKU: orb3027219

Description

PS372424 hydrochloride is a synthetic tripeptide agonist of the human CXCR3 receptor derived from CXCL10. It exhibits anti-inflammatory properties by inhibiting T-cell migration, as demonstrated in humanized models of arthritic inflammation. This compound is a valuable research tool for studying CXCR3-mediated immune responses in both in vitro and in vivo contexts.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1596362-29-6
MW625.2
Purity95.03% (May vary between batches)
FormulaC33H45ClN6O4
SMILESC(N[C@H](C(NCC1CCCCC1)=O)CCCNC(=N)N)(=O)[C@H]2N(C(CCC(=O)C3=CC=CC=C3)=O)CC=4C(C2)=CC=CC4.Cl
TargetCXCR
SolubilityDMSO:200 mg/mL (319.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8 mM)

Bioactivity

In Vitro
In cells expressing CXCR3-A, stimulation with PS372424 hydrochloride resulted in a peak in intracellular calcium levels after 20 seconds, and after 5 minutes of stimulation, PS372424 increased phosphorylated p-Erk1 and phosphorylated p-Erk2 in U87-CXCR3-A cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PS 372424 hydrochloride
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Quality Guarantee

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Protocol Information

Available Sizes

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1 mg
$ 140.00
DispatchUsually dispatched within 5-10 working days
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