PSMD2 (N) Antibody, Rabbit Polyclonal

SKU: orb131870

Description

Rabbit polyclonal to PSMD2. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD2 is one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, PSMD2 may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution Range	WB:1:1000-1:3000
Reactivity	Human
Application Notes	WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human PSMD2.

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human PSMD2
Molecular Weight	100
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Concentration	100 μg/ml BSA
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti 26S proteasome non-ATPase regulatory subunit 2 antibody, anti 26S proteasome regulatory subunit RPN1 antibody, anti 26S proteasome regulatory subunit S2 antibody, anti 26S proteasome subunit p97 antibody, anti Protein 55.11 antibody, anti Tumor necrosis factor type 1 receptor-associated protein 2 antibody, anti TRAP2 antibody, anti MGC14274 antibody, anti P97 antibody, anti Rpn1 antibody, anti S2 antibody

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Quick Database Links

UniProt

Q13200

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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