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PSN 375963

SKU: orb1305698

Description

PSN 375963 hydrochloride is a synthetic GPR119 agonist used in research to study metabolic pathways. It is applied in both in vitro assays and in vivo models to investigate its potential role in glucose homeostasis and insulin secretion.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number388575-52-8
MW285.38
Purity99.24% (May vary between batches)
FormulaC17H23N3O
SMILESCCCCC1CCC(CC1)c1nc(no1)-c1ccncc1
TargetGPCR
SolubilityDMSO:4 mg/mL (14.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.5 mM);Ethanol:24 mg/mL (84.1 mM)

Bioactivity

Target IC50
GPR119:7.9 μM(EC50,mouse)|GPR119:8.4(EC50,human)
In Vivo
PSN 375963 suppressed food intake in rats and reduced body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats.
In Vitro
PSN 375963 is a potent GPR119 agonist with EC50s of 8.4 and 7.9 μM for human and mouse GPR119.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cAMP, orphan, endogenous, GPR119, G Protein-Coupled Receptor 119, PSN375963, PSN-375963, PSN375963 Hydrochloride, PSN-375963 Hydrochloride, PSN 375963, PSN 375963 hydrochloride

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 80.00
25 mg
$ 120.00
50 mg
$ 160.00
100 mg
$ 240.00
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