Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

PW0464

SKU: orb1693301

Description

PW0464 ((Rac)-Razpipadon) is a potent, non-catechol, and G protein-biased dopamine D1 receptor agonist (Gs-cAMP EC50 = 5.8 nM). It serves as a valuable research tool for investigating D1R signaling in neurological disorders, with applications in both in vitro signaling studies and in vivo models of Parkinson's disease and cognitive dysfunction.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1643462-93-4
MW389.35
Purity98.78% (May vary between batches)
FormulaC19H17F2N3O4
SMILESO=C1NC(=O)N(C(C=2C=CC(OC3=NC=CC=C3OC(F)F)=CC2C)=C1C)C
TargetDopamine Receptor
Solubility10% DMSO+90% Corn Oil:1.5 mg/mL (3.85 mM);DMSO:18 mg/mL (46.23 mM)

Bioactivity

Target IC50
cAMP assay (HEK293T cells):5.8 nM (EC₅₀)
In Vitro
PW0464 is a non-catechol selective dopamine D1/D5 receptor agonist. In HEK293T cells overexpressing D1R or D5R, PW0464 activates G-protein signaling (cAMP production) with an EC₅₀ of 5.8 nM, indicating high potency.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(Rac)-Razpipadon, PW 0464, PW0464, PW-0464
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 200.00
5 mg
$ 440.00
1 ml x 10 mM (in DMSO)
$ 480.00
10 mg
$ 710.00
25 mg
$ 1,320.00
50 mg
$ 2,020.00
100 mg
$ 2,700.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry