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PX20350

SKU: orb3173161

Description

PX20350 is an FXR agonist with EC50 values of 83 nM for mFXR and 10 nM for hFXR. It significantly induces NDRG2 mRNA expression. PX20350 effectively inhibits the growth and metastasis of liver tumor cells (SK-GI-18 cells) and exhibits antitumor activity in orthotopic xenograft mouse models.

Images & Validation

Key Properties

CAS Number1198085-23-2
MW592.4
FormulaC28H22Cl2F3N3O4
SMILESO=C(O)C1=CC=C(C=C1)CN(C2=CC=C(N=C2C(F)(F)F)OCC=3C(=NOC3C4CC4)C=5C(Cl)=CC=CC5Cl)C
TargetFXR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information