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Pyoluteorin

SKU: orb1704973

Description

Pyoluteorin is a small-molecule antibiotic active against oomycete pathogens like Pythium ultimum. It also induces apoptosis in human triple-negative breast cancer MDA-MB-231 cells in vitro, making it a compound of interest in plant pathology and oncology research.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number25683-07-2
MW272.08
Purity>99.99% (May vary between batches)
FormulaC11H7Cl2NO3
SMILESOc1cccc(O)c1C(=O)c1cc(Cl)c(Cl)[nH]1
TargetApoptosis,Antifungal,Antibiotic
SolubilityDMSO:55 mg/mL (202.15 mM)

Bioactivity

In Vitro
Pyoluteorin, an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, was identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5. It exhibits significant cytotoxicity towards MCF-7 cells (IC50=1.84 μM) and selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50 values of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively. Treatment with Pyoluteorin (0.1-10 μM; for 24 hours) induces changes in apoptosis-related protein expressions and promotes cell apoptosis in MDA-MB-231 cells via Bcl-2 family proteins and caspase cascade, additionally causing cell cycle arrest in these human triple-negative breast cancer cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Antibiotic, Pyoluteorin
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Key Properties

No computed properties available.

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Pyoluteorin (orb1704973)

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Available Sizes

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1 mg
¥ 3,120.00
1 ml x 10 mM (in DMSO)
¥ 6,370.00
5 mg
¥ 7,020.00
10 mg
¥ 9,620.00
25 mg
¥ 14,560.00
50 mg
¥ 19,370.00
100 mg
¥ 26,000.00
500 mg
¥ 51,610.00
DispatchUsually dispatched within 3-5 working days
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