Pyrazoloacridine

SKU: orb1304938

Description

Pyrazoloacridine (PD 115934) is a dual topoisomerase I/II inhibitor with an IC50 of 1.25 μM in K562 cells. This nucleic acid-binding agent exhibits anticancer activity and has been investigated in both in vitro cytotoxicity assays and in vivo preclinical tumor models.

Research Area

Cell Biology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	99009-20-8
MW	367.4
Purity	99.72% (May vary between batches)
Formula	C₁₉H₂₁N₅O₃
SMILES	COc1ccc2[nH]c3c(ccc4n(CCCN(C)C)nc(c34)c2c1)[N+]([O-])=O
Target	Topoisomerase,Apoptosis
Solubility	DMSO:5.22 mg/mL (14.21 mM)

Bioactivity

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In Vitro	In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, carcinoma, Inhibitor, NSC366140, NSC-366140, NSC 366140, myeloid, inhibit, Pyrazoloacridine, pancreatic, PD115934, PD-115934, PD 115,934, PD 115934, leukemia, solid, tumor, Topo I, Topo II, Topoisomerase

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Compound Identifiers

PubChem CID

339455 ↗

Key Properties

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No computed properties available.

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