Pyridone 6

SKU: orb1304561

Description

Pyridone 6

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	457081-03-7
MW	309.34
Purity	98.74%
Formula	C₁₈H₁₆FN₃O
SMILES	CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O
Target	JAK,Tyrosine Kinases
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.47 mM);DMSO:12 mg/mL (38.79 mM)

Bioactivity

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Target IC50	IκB Kinase 2:0.3 μM\|CDK2:3.3 μM\|TYK2:1 nM\|Csk:2.1 μM\|KDR:1.4 μM\|Tek:24 μM\|Hck:7.7 μM\|PDGFR:1.49 μM\|MAPK:1.78 μM\|JAK2:1 nM\|JAK1:15 nM\|MEK:0.16 μM\|FLT1:1.52 μM\|FGFR:1.48 μM\|JAK3:5 nM(Ki)\|p38:11 μM\|FLT4:0.69 μM\|PKCα:1.2 μM\|FGFR2:0.94 μM\|Fyn T:0.5 μM\|cAMP stimulated protein kinase:7.1 μM Read more...
In Vivo	Pyridone 6 (P6) postpone the initiation and diminishe the severity of skin conditions in an AD-like model using NC/Nga mice, effectively mitigating atopic dermatitis (AD) symptoms. Its efficacy is on par with betamethasone ointment, a s andard treatment, also serving as a positive control. Conversely, empty PLGA nanoparticles (C-nano) appear ineffectiv. Read more...
In Vitro	Pyridone 6 (P6) is shown to inhibit kinase by interacting withi the ATP-binding cleft of Each JAK the IC50 of Pyridone 6 is 3 nM for All of these cytokines; this is comparable to the reported IC50 of Pyridone 6 for JAK2, Tyk2, and JAK3. Pyridone 6 strongly inhibits Th2 and modestly inhibits Th1, whereas it enhances Th17 development when present within a certain range of concentration . Pyridone 6 reduces IFN-γ and IL-13, whereas it enhances IL-17 and IL-22 expression. Pyridone 6 also inhibits both Th1 and Th2 development, whereas it promotes Th17 differentiation from naive T cells when present within a certain range of concentration Pyridone 6 inhibits osteoclast differentiation in mouse bone marrow macrophage (BMM) cultures stimulated b the receptor activator of nuclear factor-k B (NF-k B) li and (RANKL) and co-cultures of bone marrow cells and osteoblasts. Pyridone 6 suppresse the expression of c-Fos and nuclear factor of activated T cells (NFAT) c1 in BMMs. Pyridone 6 also suppresses I-k B degradation and extracellular signal-regulated kinase (ERK) in mature osteoclasts, suggesting that these ar the key molecules that pyridone 6 targets in the Inhibition of osteoclast functio. Pyridone 6 (P6), is found to inhibi the JAKs in the low nanomolar range IC50 1-15 nM) and blocks IL-2-dependent proliferation of CTLL cells. Pyridone 6 is a reversible ATP inhibitor, and when tested against many Other kinases, IC50 of >130 nM are require. Read more...
Cell Research	Pyridone 6 (P6) is prepared in DMSO and stored, and then diluted with appropriate medium before us. naive CD4+ T cells are treated with various concentration of Pyridone 6 in RPMI 1640 medium 1 h befor the appropriate cytokines are added to create Each Th-differentiating condition. Immunoblotting is performed using antiphospho-STAT protein Abs or anti-total STAT protein Ab. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CMP6, CMP-6, CMP 6, JAK2, JAK3, Janus-Associated Kinase Inhibitor I, JAK, JAK1, JAK Inhibitor, JAK Inhibitor I, JAK I inhibitor, Pyridone 6, Pyridone-6, Pyridone6, TyrosineKinases, Tyrosine Kinases, Tyk2

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Compound Identifiers

PubChem CID

5494425 ↗

Key Properties

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No computed properties available.

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Purity:	>98%(HPLC)
CAS Number:	457081-03-7
MW:	309.3
Formula:	C₁₈H₁₆FN₃O

Pyridone 6

Description

Research Area

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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