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(R)-(+)-Bay-K-8644

SKU: orb2900176

Description

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

Images & Validation

Key Properties

CAS Number98791-67-4
MW356.3
Purity>98% (HPLC)
FormulaC16H15F3N2O4
SMILESCOC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
TargetPPAR
SolubilityIn Vitro: DMSO : ≥ 300 mg/mL (841.99 mM)

Bioactivity

In Vitro
(R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50 = 975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644IBa. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • (R)-(+)-Bay-K-8644 [orb1679037]

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    98791-67-4

    356.3

    C16H15F3N2O4

    1 mg, 1 ml x 10 mM (in DMSO), 2 mg, 5 mg
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Protocol Information

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