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(R)-DOI hydrochloride

SKU: orb1740860

Description

(R)-DOI hydrochloride is a potent and selective agonist for serotonin receptors 5-HT2A and 5-HT2C. This orally active compound is used in neuroscience research to study receptor function, signal transduction, and the mechanisms underlying hallucinogenic effects in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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(R)-DOI hydrochloride

Key Properties

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CAS Number82864-02-6
MW357.62
Purity99.88% (May vary between batches)
FormulaC11H17ClINO2
SMILESC([C@@H](C)N)C1=C(OC)C=C(I)C(OC)=C1.Cl
Target5-HT Receptor

Bioactivity

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In Vivo
In vivo, intracerebroventricular infusion of (R)-DOI hydrochloride in turkeys significantly increased plasma prolactin (PRL) levels (by 40% at 5 min post-infusion, peaking at 20 min). (R)-DOI hydrochloride also activated hypothalamic dopaminergic (TH-positive) and vasoactive intestinal peptide (VIP-positive) neurons, as indicated by c-fos mRNA expression co-localization (POM: 9.2%, PMM: 44.6%, ML: 28.6%; VIP neurons: 13.2%), suggesting its role in PRL regulation via neuronal activation.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
11957541 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 340.00
5 mg
$ 770.00
10 mg
$ 1,030.00
25 mg
$ 1,560.00
50 mg
$ 2,020.00
100 mg
$ 2,540.00
DispatchUsually dispatched within 6-8 weeks
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