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(Rac)-Sabcomeline HCl

SKU: orb1819146

Description

Sabcomeline HCl is a selective M1 muscarinic acetylcholine receptor agonist used in Alzheimer's disease research. It is employed in both in vitro and in vivo studies to investigate cholinergic signaling, cognitive function, and potential therapeutic strategies for neurodegenerative disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number133642-67-8
MW229.71
Purity99.03% (May vary between batches)
FormulaC10H16ClN3O
SMILESCl.N#CC(=NOC)C1CN2CCC1CC2
TargetAChR
SolubilityDMSO:50 mg/mL (217.67 mM)

Bioactivity

In Vivo
Sabcomeline HCl dose-dependently increased dopamine efflux in the medial prefrontal cortex but only a high dose of sabcomeline HCl (1 mg/kg; s.c.; rats) increased that in the nucleus accumbens. According to the analysis of net-AUC (area under the curve) values of acetylcholine and dopamine levels, the rank order of ability of these drugs to increase acetylcholine or dopamine levels is sabcomeline HCl>xanomeline approximately AC260584>N-desmethylclozapine.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

muscarinic receptor, Sabcomeline HCl, sabcomeline HCl(149156-36-5 Free base)
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 240.00
5 mg
$ 470.00
10 mg
$ 680.00
25 mg
$ 1,030.00
50 mg
$ 1,400.00
100 mg
$ 1,870.00
DispatchUsually dispatched within 3-5 working days
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