(Rac)-Sabcomeline HCl

SKU: orb1819146

Description

Sabcomeline HCl is a selective M1 muscarinic acetylcholine receptor agonist used in Alzheimer's disease research. It is employed in both in vitro and in vivo studies to investigate cholinergic signaling, cognitive function, and potential therapeutic strategies for neurodegenerative disorders.

Research Area

Neuroscience

Images & Validation

−

Key Properties

−

CAS Number	133642-67-8
MW	229.71
Purity	99.58%
Formula	C₁₀H₁₆ClN₃O
SMILES	Cl.N#CC(=NOC)C1CN2CCC1CC2
Target	AChR
Solubility	DMSO:50 mg/mL (217.67 mM)

Bioactivity

−

In Vivo

Sabcomeline HCl dose-dependently increased dopamine efflux in the medial prefrontal cortex but only a high dose of sabcomeline HCl (1 mg/kg; s.c.; rats) increased that in the nucleus accumbens. According to the analysis of net-AUC (area under the curve) values of acetylcholine and dopamine levels, the rank order of ability of these drugs to increase acetylcholine or dopamine levels is sabcomeline HCl>xanomeline approximately AC260584>N-desmethylclozapine.

Storage & Handling

−

Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

muscarinic receptor, Sabcomeline HCl, sabcomeline HCl(149156-36-5 Free base)

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

85038833 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols