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(Rac)-WAY-161503

SKU: orb1708232

Description

(Rac)-WAY-161503 is a potent and selective 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. This compound has demonstrated anti-obesity and antidepressant-like effects in preclinical in vivo studies, making it a valuable research tool for investigating central nervous system disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number75704-24-4
MW272.13
Purity99.51%
FormulaC11H11Cl2N3O
SMILESClc1cc2NC(=O)C3CNCCN3c2cc1Cl
Target5-HT Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.13 mM);DMSO:90 mg/mL (330.72 mM)

Bioactivity

Target IC50
5-HT2C receptor:12 nM (EC50)|5-HT2C receptor:4 nM(Ki)
In Vivo
In male C57BL/6J mice, (Rac)-WAY-161503 (3-30 mg/kg; i.p.) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082. Additionally, in the 5-HT2A KO mice, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5-HT2C Receptor, 5-HT2C, 5HTReceptor, 5HT Receptor, (Rac) WAY 161503, (Rac)WAY161503, WAY161503, WAY-161503, WAY 161503
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

(Rac)-WAY-161503 (orb1708232)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
¥ 1,690.00
10 mg
¥ 2,080.00
25 mg
¥ 3,120.00
50 mg
¥ 4,160.00
100 mg
¥ 5,980.00
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