Rauwolscine hydrochloride

SKU: orb1302866

Description

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	6211-32-1
MW	390.9
Purity	100.00%
Formula	C₂₁H₂₇ClN₂O₃
SMILES	Cl.[H][C@]12CC[C@H](O)[C@@H](C(=O)OC)[C@@]1([H])C[C@]1([H])N(CCc3c1[nH]c1ccccc31)C2
Target	Adrenergic Receptor
Solubility	H2O:5 mM;DMSO:13.75 mg/mL (35.18 mM)

Bioactivity

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Target IC50

α2-adrenoceptor:12 nM (Ki)

In Vitro

[3H]Rauwolscine binding to the α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low-affinity states of the α2 adrenergic receptor in brain membranes. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [3H]5-HT as a radioligand, rauwolscine is determined to have a relatively high affinity for the human receptor (Ki: 14.3/35.8 nM, for human and rat). Saturation studies show that the affinity of [3H]Rauwolscine is similar in mouse, rabbit, rat, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Adrenergic Receptor, AdrenergicReceptor, a-Yohimbine Hydrochloride, alpha-Yohimbine Hydrochloride, Corynanthidine, Corynanthidine Hydrochloride, Corynanthidine hydrochloride, Beta Receptor, inhibit, Isoyohimbine, Isoyohimbine Hydrochloride, Isoyohimbine hydrochloride, Inhibitor, α-Yohimbine, α-Yohimbine Hydrochloride, α-Yohimbine hydrochloride, α2 adrenergic receptor, Rauwolscine, Rauwolscine hydrochloride, Rauwolscine Hydrochloride

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Compound Identifiers

PubChem CID

197067 ↗

Key Properties

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No computed properties available.

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