Research Grade Coltuximab Antibody

SKU: orb2978461

Description

Coltuximabravtansine(SAR3419)isanantibody-drugconjugate(ADC)targetingCD19createdbyconjugatingaderivativeofthepotentmicrotubule-actingcytotoxicagent,maytansine,toaversionoftheanti-CD19antibody,anti-B4,thatwashumanizedasanIgG1byvariabledomainresurfacing.Fourdifferentlinker-maytansinoidconstructsweresynthesized(average∼3.5maytansinoids/antibodyforeach)toevaluatetheimpactoflinker-payloaddesignontheactivityofthemaytansinoid-ADCstargetingCD19.Anti-CD19humanizedmonoclonalantibodyconjugatedtoDM4.

Images & Validation

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Tested Applications	ELISA, FA, FACS, In vivo
Reactivity	Human

Key Properties

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Antibody Type	Biosimilar Antibody
Host	Chimeric
Clonality	Monoclonal
Isotype	IgG1-kappa
Source/Expression System	Mammalian Cells
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Endotoxin	Please contact with the lab for this information.
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/Appearance	Liquid
Buffer/Preservatives	0.01M PBS, pH 7.4.
Concentration	1mg/ml
Disclaimer	For research use only

Alternative Names

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SAR3419,CAS:1269764-99-9

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Protocol Information

FACS

Fluorescence-Activated Cell Sorting (FC, Flow cytometry)

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ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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