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RH1

SKU: orb1706722

Description

RH1 (NSC 697726) is a bioreductive prodrug investigated for its anticancer properties. It demonstrates a concentration-dependent dual response in vitro, triggering cellular senescence at lower concentrations and apoptotic cell death at higher doses. This compound is utilized in cancer research, particularly in studies exploring hypoxia-targeted therapies and mechanisms of cell fate.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number221635-42-3
MW234.25
Purity99.15%
FormulaC12H14N2O3
SMILESO=C1C(=C(C(=O)C(=C1C)N2CC2)CO)N3CC3
TargetOthers,Apoptosis
SolubilityDMSO:1 mg/mL (4.27 mM)

Bioactivity

In Vivo
RH1 exhibited dose-dependent antitumor activity against NQ16 tumors grown in thymus-free mice. A small dose of RH1 (0.1 mg/kg) also resulted in a significant reduction in tumor size in treated mice compared to controls. Treatment of mice with NQ16 tumors with RH1 (0.4 mg/kg and 0.2 mg/kg) resulted in a significant reduction in tumor size between the treated and control groups as early as 5 days after the end of the treatment period .
In Vitro
RH1 causes apoptosis in NQ16 cells in a time- and concentration-dependent manner. Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 minutes resulted in a significant (p< 0.05) increase in cross-linked DNA .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, NSC697726, NSC-697726, NSC 697726, RH1, RH-1, RH 1

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Key Properties

No computed properties available.

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Protocol Information

RH1 (orb1706722)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 3,120.00
5 mg
¥ 6,370.00
10 mg
¥ 9,880.00
25 mg
¥ 19,370.00
50 mg
¥ 26,260.00
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