Rilmenidine Phosphate

SKU: orb1221725

Description

Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.(In Vitro):Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation.(In Vivo):Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.Rilmenidine phosphate decreases levels of mutant huntingtin.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	85409-38-7
MW	278.24
Purity	>98% (HPLC)
Formula	C₁₀H₁₉N₂O₅P
SMILES	C1CC1C(C1CC1)NC1=NCCO1.OP(=O)(O)O
Target	I(1) imidazoline receptor
Solubility	In Vitro: H2O : 83.33 mg/mL (299.49 mM)

Bioactivity

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In Vivo

Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age. Rilmenidine phosphate decreases levels of mutant huntingtin.

In Vitro

Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors. Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation. Cell Proliferation Assay Cell line: K562 cells. Concentration: 25, 50, 100 μM. Incubation time: 24 hours. Result: Dose-dependently inhibited K562 colony formation.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

I(1) imidazoline receptor

Protocol Information

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Purity:	98.00% (May vary between batches)
CAS Number:	85409-38-7
MW:	278.24
Formula:	C₁₀H₁₉N₂O₅P