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Rivanicline 2HCl

SKU: orb1819290

Description

Rivanicline dihydrochloride is a selective inhibitor of neuronal nicotinic acetylcholine receptors, exhibiting high affinity for the α4β2 subtype. It is utilized in neuroscience research to investigate receptor function and has been applied in both in vitro binding assays and in vivo studies related to nicotine dependence.

Research Area

Neuroscience

Images & Validation

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Rivanicline 2HCl

Key Properties

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MW235.15
Purity99.40% (May vary between batches)
FormulaC10H16Cl2N2
SMILESCNCC/C=C/C1=CN=CC=C1.Cl.Cl
TargetAChR
SolubilityDMSO:50 mg/mL (212.63 mM)

Bioactivity

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In Vivo
When Trop-2-expressing tumors are subcutaneously injected into animal models, they exhibit a remarkable reduction in growth upon treatment with specific drugs targeting Akt activity. This underscores the central functional role of Akt in mediating the Trop-2-dependent growth stimulus.
In Vitro
The study investigates the impact of selectively inhibiting Akt in proliferating cells that express Trop-2. In cells expressing Trop-2, Akt inhibition, whether achieved through silencing or specific drugs, significantly reduces cell proliferation in a dose-dependent manner.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Rivanicline, Rivanicline 2HCl, Rivanicline 2HCl(15585-43-0 Free base), α4β2 nAChR
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
138958656 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 70.00
5 mg
$ 110.00
10 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 160.00
25 mg
$ 300.00
50 mg
$ 510.00
100 mg
$ 730.00
DispatchUsually dispatched within 3-5 working days
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Distributors

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