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Ro 10-5824 dihydrochloride

SKU: orb1309150

Description

Ro 10-5824 dihydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number189744-94-3
MW353.29
Purity99.95% (May vary between batches)
FormulaC17H22Cl2N4
SMILESCl.Cl.Cc1ncc(CN2CCC(=CC2)c2ccccc2)c(N)n1
TargetDopamine Receptor
SolubilityH2O:60 mg/mL (169.83 mM);DMSO:8.33 mg/mL (23.58 mM)

Bioactivity

Target IC50
D4 receptor:5.2 nM (ki)
In Vivo
The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice.
In Vitro
RO-10-5824 exhibits high affinity binding (Ki=5.2±0.9 nM (n=3)), 250-fold selectivity over human D3R, and >1000-fold selectivity for D4 versus human D2, D1, and D5 receptors. It stimulates 35S-GTPγS binding (EC50: 205±67 nM) (n=7) with a maximal induction of 36±4% above basal level .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

D4, DopamineReceptor, Dopamine Receptor, dopamine D4 receptor, Inhibitor, inhibit, Ro 10 5824 dihydrochloride, Ro 10-5824, Ro 105824 dihydrochloride, Ro 10-5824 Dihydrochloride

Similar Products

  • Ro 10-5824 dihydrochloride [orb1940767]

    >98% (HPLC)

    189744-94-3

    353.29

    C17H22Cl2N4

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 90.00
25 mg
$ 110.00
50 mg
$ 170.00
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