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Ro 67-7476

SKU: orb1304163

Description

Ro 67-7476 is a potent and selective positive allosteric modulator of rat mGluR1a (EC50 = 60.1 nM), enhancing glutamate-induced calcium release. It also acts as a P-ERK1/2 agonist, independently stimulating ERK1/2 phosphorylation (EC50 = 163.3 nM). This compound is a valuable research tool for studying mGluR1 signaling in neurological disease models, both in vitro and in vivo.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number298690-60-5
MW319.39
Purity99.48% (May vary between batches)
FormulaC17H18FNO2S
SMILESCc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1
TargetGluR
SolubilityDMSO:50 mg/mL (156.55 mM)

Bioactivity

Target IC50
mGluR1a:60.1 nM (EC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cAMP accumulation, Inhibitor, excitatory postsynaptic potentials, Metabotropic glutamate receptors, mGluR, mGluR1, neuronal culture, inhibit, traumatic injury, Ro 67 7476, Ro 677476, Ro 67-7476

Similar Products

  • Ro 67-7476 [orb1223161]

    >98% (HPLC)

    298690-60-5

    319.39

    C17H18FNO2S

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 340.00
50 mg
$ 590.00
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