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Ro0711401

SKU: orb1217708

Description

Ro0711401 is an agonist of mGlu1 receptor.

Images & Validation

Key Properties

CAS Number714971-87-6
MW360.29
Purity>98% (HPLC)
FormulaC18H11F3N2O3
SMILESO=C(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)NC4=NC(C(F)(F)F)=CO4
TargetGluR
SolubilityDMSO : 100 mg/mL (277.55 mM; Need ultrasonic)

Bioactivity

In Vivo
RO0711401 (10 mg/kg; s. c. ; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days. Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice. Animal model: Spinocerebellar ataxia type 1 (SCA1) mice (30-week old). Dosage: 10 mg/kg. Administration: Subcutaneous injection; once. Result: Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ro-0711401 | Ro 0711401

Similar Products

  • Ro0711401 [orb1298439]

    97.57% (May vary between batches)

    714971-87-6

    360.29

    C18H11F3N2O3

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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2 mg
$ 130.00
5 mg
$ 210.00
10 mg
$ 320.00
25 mg
$ 710.00
50 mg
$ 1,040.00
100 mg
$ 1,480.00
500 mg
$ 2,950.00