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Ro24-7429

SKU: orb1304922

Description

Ro24-7429

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number139339-45-0
MW272.73
Purity99.29%
FormulaC14H13ClN4
SMILESCNC1=Nc2ccc(Cl)cc2C(=NC1)c1ccc[nH]1
TargetHIV Protease,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.67 mM);DMSO:140 mg/mL (513.33 mM)

Bioactivity

Target IC50
C8166 cells:0.7 μM
In Vivo
Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model.
In Vitro
Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, antifibrotic, anti-inflammatory, anti-HIV, inhibit, Human immunodeficiency virus, Inhibitor, HIV, HIV Protease, HIV-1, HIVProtease, Tat, RUNX1, Ro247429, Ro-24-7429, Ro24-7429, Ro 247429, Ro 24-7429, Ro24 7429
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Ro24-7429 (orb1304922)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,690.00
5 mg
¥ 3,120.00
1 ml x 10 mM (in DMSO)
¥ 3,510.00
10 mg
¥ 4,680.00
25 mg
¥ 7,540.00
50 mg
¥ 10,530.00
100 mg
¥ 14,560.00
500 mg
¥ 39,910.00
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