Cart summary

You have no items in your shopping cart.

RO495

SKU: orb1305941

Description

RO495 (CS-2667) is a highly potent and selective TYK2 inhibitor, demonstrating an IC50 of 1.5 nM in cellular assays. This small molecule is a valuable research tool for investigating TYK2-dependent signaling in immunological and inflammatory diseases, with utility in both in vitro and in vivo preclinical studies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1258296-60-4
MW389.24
Purity99.40%
FormulaC17H14Cl2N6O
SMILESCc1cc(Nc2cc(NC(=O)c3c(Cl)cccc3Cl)ccn2)nc(N)n1
TargetJAK,Tyrosine Kinases
SolubilityDMSO:9 mg/mL (23.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM)

Bioactivity

Target IC50
TYK2:1.5nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CS2667, CS-2667, CS 2667, Inhibitor, JAK, inhibit, Janus kinase, RO495, RO-495, RO 495, Tyrosine Kinases, TyrosineKinases, TYK2

Similar Products

  • RO495 [orb1219273]

    >98% (HPLC)

    1258296-60-4

    389.2

    C17H14Cl2N6O

    50 mg, 25 mg, 1 g, 500 mg, 200 mg, 5 mg, 10 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

RO495 (orb1305941)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
10 mg
¥ 2,340.00
25 mg
¥ 4,030.00
50 mg
¥ 5,590.00
100 mg
¥ 7,280.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry