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RO5263397

SKU: orb1708657

Description

RO5263397 is an orally active, selective TAAR1 agonist investigated for its antidepressant potential. It also functions as a COX-2 enzyme inhibitor, implicating it in prostaglandin synthesis pathways. This dual activity makes it a useful research tool for neuropsychiatric and inflammation studies in both in vitro and in vivo models.

Images & Validation

Key Properties

CAS Number1357266-05-7
MW194.21
Purity99.37%
FormulaC10H11FN2O
SMILESCc1c(F)cccc1[C@H]1COC(N)=N1
TargetOthers
SolubilityDMSO:234 mg/mL (1204.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (25.75 mM)

Bioactivity

In Vivo
Dosing at the mid-light phase (ZT6)(RO5263397) increased wake time at 0.3 and 1 mg/kg. RO5263397 ecreases NREM time in WT mice. RO5263397 (0.3 and 1.0 mg/kg; p.o.; in OE mice) powerfully increases W time in OE mice for 5-6 h. NREM sleep is suppressed for 4-6 h and REM sleep is almost completely suppressed for 6 h after all doses of RO5263397.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

amine-associated receptor 1 (TAAR1), RO5263397, RO-5263397, RO 5263397

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  • (4R)-RO5263397 [orb1737836]

    99.34% (May vary between batches)

    1357266-80-8

    194.21

    C10H11FN2O

    1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 5 mg, 200 mg
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Key Properties

No computed properties available.

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Protocol Information

RO5263397 (orb1708657)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,560.00
5 mg
¥ 1,560.00
10 mg
¥ 2,210.00
25 mg
¥ 4,290.00
50 mg
¥ 6,500.00
100 mg
¥ 9,100.00
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