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RO8191

SKU: orb1306082

Description

RO8191

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number691868-88-9
MW373.21
Purity98.85%
FormulaC14H5F6N5O
SMILESFC(F)(F)C1=CC(=C2C=CC3=NC(=CN3C2=N1)C1=NN=CO1)C(F)(F)F
TargetSTAT,IFNAR,JAK,HCV Protease,HBV
SolubilityDMSO:3 mg/mL (8.04 mM)

Bioactivity

In Vivo
RO8191 significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.
In Vitro
RO8191 strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels o the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region o the replicon cell.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CDM 3008, CDM3008, CDM-3008, cccDNA, Inhibitor, JAK, JAK1, Janus kinase, inhibit, ISGs, orally, EMCV, IFNAR1, IFNAR2, IFNAR, interferon, HCV, HCVProtease, HCV Protease, Hepatitis C virus, Hepatitis B virus, Interferon-alpha/beta receptor, Interferon-α/β receptor, HBV, imidazonaphthyridine, STAT, RO8191, RO-8191, RO4948191, RO-4948191, RO 4948191, RO 8191, replicon, Tyk2
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

RO8191 (orb1306082)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,040.00
2 mg
¥ 1,300.00
5 mg
¥ 1,690.00
10 mg
¥ 2,470.00
25 mg
¥ 4,290.00
50 mg
¥ 6,110.00
100 mg
¥ 8,840.00
500 mg
¥ 17,680.00
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