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ROCK2-IN-12

SKU: orb3173782

Description

ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.

Images & Validation

Key Properties

CAS Number3086603-12-2
MW455.46
FormulaC23H18FN9O
SMILESFC1=CC=C(C=C1)CNCC2=NC(=NO2)C3=CN=C4C=CC(=NN43)NC=5C=CC=6NN=CC6C5
TargetSTAT,ROCK,TGF-beta/Smad

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information