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ROCK/HDAC-IN-1

SKU: orb2802262

Description

ROCK/HDAC-IN-1 (Compound 10h) is an orally active dual inhibitor of ROCK1/2 and HDAC1/2/3/6/8. It demonstrates potent antiproliferative activity in breast cancer cells, induces immunogenic cell death markers like CRT and HMGB1, and shows in vivo antitumor efficacy with T cell activation and low toxicity.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW386.47
FormulaC19H22N4O3S
SMILESO=C(NCCCCCCC(NO)=O)C1=CC2=CC(C3=CNN=C3)=CC=C2S1
TargetEpigenetic Reader Domain,HDAC,ROCK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information