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RORγt Inverse agonist 6

SKU: orb1309153

Description

RORγt Inverse agonist 6 is a potent synthetic ligand that acts as an inverse agonist of the RORγt nuclear receptor. It is a valuable research tool for studying Th17 cell biology and has demonstrated utility in both cellular assays and animal models of autoimmune diseases.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1887161-80-9
MW565.02
Purity98.65% (May vary between batches)
FormulaC28H29ClN6O5
SMILESCC(C)n1c2ccc(NC(=O)N3CCO[C@H](C3)C(=O)Nc3ccc(C#N)c(Cl)c3)cc2c(=O)n(CC2CC2)c1=O
TargetROR
Solubility10% DMSO+90% Corn Oil:2 mg/mL (3.54 mM);DMSO:45 mg/mL (79.64 mM)

Bioactivity

In Vivo
RORγt Inverse agonist 6 (30 mg/kg; p.o.) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose. RORγt Inverse agonist 6 suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model. RORγt Inverse agonist 6 (1 mg/kg; p.o.) exhibits improved drug exposure with AUC of 1289 ng h/mL.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RAR-related orphan receptor, RORgammat Inverse agonist 6, ROR, RORrt Inverse agonist 6, RORγt, RORγt Inverse agonist 6, RORγt Inverse agonist6, RORγt Inverse agonist-6, inhibit, Inhibitor

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 220.00
10 mg
$ 260.00
25 mg
$ 380.00
50 mg
$ 510.00
100 mg
$ 640.00
200 mg
$ 830.00
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