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RS 09 TFA

SKU: orb1981505

Description

RS 09 TFA is a synthetic TLR4 agonist and LPS-mimetic peptide that activates NF-κB signaling, driving pro-inflammatory cytokine production in macrophages like RAW264.7 cells. It is utilized in immunology research to study macrophage polarization, neuroinflammation, and the disruption of ciliary neuroprotective pathways in both cellular and animal models.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

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RS 09 TFA

Key Properties

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MW805.8
Purity99.78% (May vary between batches)
FormulaC33H50F3N9O11
SMILESO=C([C@@H]1CCCN1C([C@@H](N)C)=O)N2CCC[C@H]2C(N[C@@H](CC3=CNC=N3)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
TargetTLR,Immunology/Inflammation related,NF-κB
SolubilityDMSO:≥ 80 mg/mL;H2O:≥ 40 mg/mL;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (4.1 mM)

Bioactivity

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In Vivo
RS 09 TFA serves as an immune adjuvant, combined with the prostate cancer-specific antigen X-15 (conjugated to the carrier protein KLH) for immunization in BALB/c mice. Experimental results demonstrate that this compound can significantly elevate the concentration of X-15-specific antibodies in the mice .
In Vitro
In HEK-BLUETM-4 cells, RS 09 TFA (1-10 μg/mL, 24 hours) can stimulate TLR-4 and activate NF-κB. In RAW264.7 cells, RS 09 TFA (5 μg/mL, 15 minutes-24 hours) binds to TLR-4 and induces NF-κB nuclear translocation as well as the secretion of inflammatory cytokines.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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RS09 TFA, RS-09 TFA
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol
TLR,Immunology/Inflammation related,NF-κB

Protocol Information

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Available Sizes

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1 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 200.00
25 mg
$ 330.00
50 mg
$ 480.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry
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