RS 67333 hydrochloride

SKU: orb1704135

Description

RS 67333 hydrochloride is a selective 5-HT4 receptor partial agonist (pKi 8.7) with neuroprotective properties. It is used in Alzheimer's disease research, showing efficacy in both in vitro assays and in vivo models to study cognitive enhancement and neuroprotection.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	168986-60-5
MW	389.36
Purity	99.76%
Formula	C₁₉H₃₀Cl₂N₂O₂
SMILES	Cl.O=C(C=1C=C(Cl)C(N)=CC1OC)CCC2CCN(CCCC)CC2
Target	5-HT Receptor
Solubility	H2O:9 mg/mL (23.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.14 mM)

Bioactivity

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Target IC50	5-HT4 receptor:8.7 (pKi)
In Vitro	RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT . Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5HT Receptor, 5-HT4, 5HTReceptor, RS67333, RS-67333, RS67333 Hydrochloride, RS-67333 Hydrochloride, RS 67333, RS 67333 (hydrochloride), RS 67333 HCl, RS 67333 Hydrochloride

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Compound Identifiers

PubChem CID

9800491 ↗

Key Properties

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No computed properties available.

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