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RTIOXA-43

SKU: orb2565339

Description

RTIOXA-43 is a dual orexin receptor (OX1R/OX2R) agonist used in research to promote wakefulness and reduce sleep attacks. It is a valuable tool for in vitro and in vivo studies investigating narcolepsy, sleep/wake neurobiology, and orexin signaling pathways.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2832067-72-6
MW663.79
Purity99.17%
FormulaC37H37N5O5S
SMILESCOc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2cccc(C)c2)c1)-c1cccc(c1)C(=O)N(C)Cc1ccncc1
TargetOX Receptor
SolubilityDMSO:80 mg/mL (120.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.97 mM)

Bioactivity

Target IC50
OX2 recepter:2 nM (EC50)|OX1 receptor:2 nM (EC50)
In Vivo
Methods: Orexin modulation was induced in middle-aged (12 months) mice by peripheral injection o the s All molecule orexin receptor agonist RTIOXA-133. Sleep-wake variables were measured by telemetry (after RTIOXA-43). Results: RTIOXA-43 improved wake time, reduced sleep duration (NREM and REM), and sleep/wake fragmentation. In addition, RTIOXA-43 improved sleep/wake quality by both reducing bout number and increasing bout duration.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

RTIOXA-43 (orb2565339)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 3,380.00
5 mg
¥ 7,540.00
1 ml x 10 mM (in DMSO)
¥ 10,790.00
10 mg
¥ 11,830.00
25 mg
¥ 23,010.00
50 mg
¥ 36,660.00
100 mg
¥ 49,400.00
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