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RTx-152

SKU: orb3134191

Description

RTx-152 is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM) that targets Polθ captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number3035072-48-8
MW479.35
FormulaC20H16F7N3O3
SMILESO=C(OC=1C(=CC(=CC1C(F)(F)F)C(F)(F)F)N2C(=O)N(C)CC2)N(C3=CC=C(F)C=C3)C
TargetDNA/RNA Synthesis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information