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(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

SKU: orb1819251

Description

MitoBloCK-6 is a potent small molecule inhibitor of the sulfhydryl oxidases Erv1/ALR (IC50 ~800 nM) and Erv2 (IC50=1.4 µM). Its mechanism involves disrupting mitochondrial redox signaling, leading to cytochrome c release and apoptosis induction, particularly studied in human embryonic stem cells (hESCs) and other in vitro models.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1934246-20-4
MW492.5
Purity99.87% (May vary between batches)
FormulaC26H23F3N6O
SMILESC[C@H]1C=2C(CN(C1)C=3C=NC=NC3)=CC(C(NC4=CC(=CC(C(F)(F)F)=C4)N5C=NC(C)=C5)=O)=CC2
TargetDiscoidin Domain Receptor (DDR)
SolubilityDMSO:45 mg/mL (91.37 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DDR, DDR1, DiscoidinDomainReceptor, DiscoidinDomainReceptor(DDR), Discoidin Domain Receptor (DDR), Discoidin Domain Receptor, (S)4methylN(3(4methyl1Himidazol1yl)5(trifluoromethyl)phenyl)2(pyrimidin5yl)1,2,3,4tetrahydroisoquinoline7carboxamide
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Key Properties

No computed properties available.

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Protocol Information

(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide (orb1819251)

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Available Sizes

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100 mg
1 mg
¥ 2,080.00
2 mg
¥ 2,860.00
5 mg
¥ 4,030.00
1 ml x 10 mM (in DMSO)
¥ 4,810.00
10 mg
¥ 5,720.00
25 mg
¥ 8,320.00
50 mg
¥ 11,440.00