(S)-(-)-Bay-K-8644

SKU: orb1940041

Description

(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.(In Vitro):The Ca2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels . FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50: 14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 . (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum.

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Key Properties

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CAS Number	98625-26-4
MW	356.301
Purity	>98% (HPLC)
Formula	C₁₆H₁₅F₃N₂O₄
SMILES	COC(=O)C1=C(C)NC(C)=C([C@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
Target	Calcium Channel
Solubility	In Vitro: DMSO : 100 mg/mL (280.66 mM)

Bioactivity

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In Vitro

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum. The Ca2+ channel activity is enhanced by 3-30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels. The interactions of two Ca2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50 = 14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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(S)-(-)-Bay K 8644

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Calcium Channel

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(S)-(-)-Bay-K-8644 (orb1940041)

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Purity:	99.37% (May vary between batches)
CAS Number:	98625-26-4
MW:	356.3
Formula:	C₁₆H₁₅F₃N₂O₄

(S)-(-)-Bay-K-8644

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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(S)-(-)-Bay-K-8644 [orb1296175]

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