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S07-2010

SKU: orb1688550

Description

S07-2010 is a potent inhibitor of AKR1C enzymes (AKR1C1-C4) with demonstrated anti-cancer activity. It induces apoptosis and exhibits significant cytotoxicity in drug-resistant cell lines such as A549/DDP and MCF-7/DOX, making it a valuable tool for studying chemoresistance and oncology research in vitro.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1223194-71-5
MW371.45
Purity98.13%
FormulaC19H21N3O3S
SMILESO=C1N=C(SCC(=O)C2=CC=C3NC(=O)CCCC3=C2)NC(=C1)CCC
TargetNADPH,Reductase,Others
SolubilityDMSO:30 mg/mL (80.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM)

Bioactivity

Target IC50
AKR1C3:0.19 μM|AKR1C1:0.47 μM|AKR1C2:0.73 μM|AKR1C4:0.36 μM
In Vitro
S07-2010 (0-25 μM, 48h) was shown to be cytotoxic to MCF-7/DOX and A549/DDP with IC50 = 127.5 and 5.51 μM. In A549/DDP cells, S07-2010 can significantly reverse cancer cell resistance to DDP and inhibit tumor proliferation at low concentrations. In A549/DDP cells, the CI values of S07-2010 ranged from 0.2 to 0.6, indicating a strong synergistic drug effect in the combination therapy. S07-2010 (25 μM) can induce apoptosis of tumor cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

S072010
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Key Properties

No computed properties available.

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S07-2010 (orb1688550)

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2 mg
¥ 1,300.00
DispatchUsually dispatched within 6-8 weeks
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