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S1P1 Agonist III

SKU: orb1706670

Description

S1P1 Agonist III is a potent and orally bioavailable S1P1 receptor agonist (EC₅₀ = 18 nM). It is a valuable research tool for investigating S1P1-mediated pathways in immunological and inflammatory processes, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1324003-64-6
MW415.37
Purity99.08% (May vary between batches)
FormulaC21H16F3N3O3
SMILESO=C(NC(=O)C=1C=NC=CC1OC)NC=2C=CC(C=3C=CC=CC3)=C(C2)C(F)(F)F
TargetS1P Receptor
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.02 mM);DMSO:48 mg/mL (115.56 mM)

Bioactivity

Target IC50
S1P1:18 nM (EC50)
In Vivo
Twenty-four hours after a single oral administration of S1P1 Agonist III (1 mg/kg) in rats, the number of circulating lymphocytes significantly decreased, with a pharmacodynamic validation value (POC) of -78% .
In Vitro
S1P1 Agonist III demonstrates superior activity against S1P1 in Parazacco spilurus subsp. spilurus (EC50=0.035 μM, efficacy reaching 96%), with selectivity exceeding 100-fold for S1P2-5 receptor subtypes .

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

S1P1 Agonist III, S-1P1 Agonist III
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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S1P1 Agonist III (orb1706670)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
5 mg
¥ 1,430.00
1 ml x 10 mM (in DMSO)
¥ 1,560.00
10 mg
¥ 1,820.00
25 mg
¥ 3,250.00
50 mg
¥ 4,680.00
100 mg
¥ 6,760.00
DispatchUsually dispatched within 5-10 working days
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