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SAG hydrochloride (912545-86-9(free base))

SKU: orb1303058

Description

SAG hydrochloride (CAS 912545-86-9 for the free base) is a potent and cell-permeable Smoothened (SMO) receptor agonist. It is widely used in research to activate the Hedgehog signaling pathway for both in vitro cellular studies and in vivo developmental biology experiments.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

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SAG hydrochloride (912545-86-9(free base))

Key Properties

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CAS Number2095432-58-7
MW526.52
Purity98.00% (May vary between batches)
FormulaC28H29Cl2N3OS
SMILESCl.CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl
TargetHedgehog/Smoothened,Smo
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.8 mM);DMSO:66 mg/mL (125.35 mM);Ethanol:38 mg/mL (72.17 mM)

Bioactivity

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In Vivo
In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.
In Vitro
SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
Animal Research
Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference)

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Hedgehog/Smoothened, Hedgehog, Smoothened Agonist HCl, Smoothened, SAG hydrochloride (912545 86 9(free base)), SAG hydrochloride (912545869(free base)), SAG hydrochloride (912545-86-9(free base))
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
121540649 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 90.00
2 mg
$ 110.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 170.00
25 mg
$ 290.00
50 mg
$ 420.00
100 mg
$ 600.00
200 mg
$ 840.00
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