SAG hydrochloride (912545-86-9(free base))

SKU: orb1303058

Description

SAG hydrochloride (CAS 912545-86-9 for the free base) is a potent and cell-permeable Smoothened (SMO) receptor agonist. It is widely used in research to activate the Hedgehog signaling pathway for both in vitro cellular studies and in vivo developmental biology experiments.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	2095432-58-7
MW	526.52
Purity	99.97%
Formula	C₂₈H₂₉Cl₂N₃OS
SMILES	Cl.CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl
Target	Hedgehog/Smoothened,Smo
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.8 mM);DMSO:66 mg/mL (125.35 mM);Ethanol:38 mg/mL (72.17 mM)

Bioactivity

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In Vivo	In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. Read more...
In Vitro	SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. Read more...
Animal Research	Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Hedgehog/Smoothened, Hedgehog, Smoothened Agonist HCl, Smoothened, SAG hydrochloride (912545 86 9(free base)), SAG hydrochloride (912545869(free base)), SAG hydrochloride (912545-86-9(free base))

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Compound Identifiers

PubChem CID

121540649 ↗

Key Properties

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No computed properties available.

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